TABROPHAGE (Metformin HCl.)

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PRESENTATION: FC tab 500 mg x 5 x 10's.
DESCRIPTION: Chemically, metformin hydrochloride is N,N-dimethylimidodcarbonimidic diamide hydrochloride.
ACTIONS: Pharmacology: Tabrophage (metformin hydrochloride) is an oral antihyperglycemic agent used in the management of non-insulin dependent diabetes mellitus (NIDDM). It improves glucose tolerance in NIDDM subjects, lowering both basal and postprandial plasma glucose. Its pharmacologic mechanisms of action are different from those of sulfonylureas. Tabrophage decreases hepatic glucose production, decreases intestinal absorption of glucose and improves insulin sensitivity (increases peripheral glucose uptake and utilization). Unlike sulfonylureas, Tabrophage does not produce hypoglycemia in either diabetic or non-diabetic subjects, and does not cause hyperinsulinemia. Tabrophage has a modest favourable effect on serum lipids, which are often abnormal in NIDDM patients. In clinical studies, particularly when baseline levels were abnormally elevated,

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HEMSAMIC (Tranexamic acid.)

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PRESENTATION: Cap 250 mg x 2 x 10's. 500 mg x 2 x 10's. lnj (amp) 250 mg/5 mL x1 x 5's. 500mg/5mlx1x5's.
DESCRIPTION: Tranexamic acid is trans-4-aminomethylcyclohexane carboxylic acid.
ACTIONS: Pharmacology: Hemsamic is a competitive inhibitor of plasminogen activation and, at much higher concentrations, a noncompetitive inhibitor of plasmin. At concentration of 1 mg/ml blood, Hemsamic does not aggregate platelets in vitro. Concentrations up to 10 mg/ml have no influence on platelet count, coagulation time or various coagulation factors in whole blood or citrated blood. On the other hand, Hemsamic in concentrations of 1 and 10 mg/ml blood prolongs thrombin time.
Pharmacokinetics: Absorption/Distribution: Absorption of Hemsamic after oral use is 30-50%; bioavailability is not affected by food. The peak plasma Ievel 3 hrs after oral administration of 1 g is 8 mg/ml. An antifibrinolytic concentration of tranexamic acid remains in various tissues for about 17 hrs and in serum up to 7 or 8 hrs.

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ORIBRO (Cefpodoxime proxetil)

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PRESENTATION: FC tab 100 mg x 1 x 10's. Susp40 mg/s mL x 50 mL, 100 mL.
DESCRIPTION: Each film-coated tablet contains cefpodoxime proxetil equivalent to cefpodoxime 100 mg. Each 5 ml suspension contains cefpodoxime proxetil equivalent to cefpodoxime 40 mg. A calibrated dosier is enclosed for administration of measured dose per kg body weight of child.
ACTIONS: Cefpodoxime proxetil is an orally administered, extended spectrum, semisynthetic antibiotic of the cephalosporin class. Cefpodoxime proxetil is a prodrug; its active metabolite is cefpodoxime.
Microbiology: Cefpodoxime is active in vitro against a wide range of gram-positive and gram-negative bacteria. Cefpodoxime is highly stable in the presence of ß-lactamase enzymes. As a result, many organisms resistant to penicillins and some cephalosporins, due to the presence of ß-lactamases, may be susceptible to cefpodoxime.

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RUMOLON (Piroxicam)

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PRESENTATION: Cap 10 mgx 1 x 10's. 20 mgx 1 x 10's. Dispersible tab 10 mg x 1 x 10's. 20 mg x 1 x 10's. lnj (amp) 20 mg/ml x 1 mL x 4's.
ACTIONS: Pharmacology: Rumolon is an effective nonsteroidal anti-inflammatory agent which inhibits prostaglandin biosynthesis as well as inhibits aggregation of neutrophils. It also possesses analgesic and antipyretic properties. Pharmacokinetics: Rumolon is completely absorbed after oral administration. Peak concentration in plasma occurs within 3-5 hrs. Neither food nor antacids affect the rate or extent of absorption. Mean half-life value appears to be about 50 hrs. This prolonged half-life results in the maintenance of relatively stable plasma concentrations throughout the day on once daily doses and to significant drug accumulation upon multiple dosing. A single 20-mg dose generally produces peak piroxicam plasma levels of 1.5-2 mcg/mL, while maximum drug plasma concentrations after repeated daily ingestion of piroxicam 20 mg

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