NEUROBION (Vitamin B-complex,)

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PRESENTATION: Film-coated tab 10 x 10’s Amp 3 mL x 25’s.
DESCRIPTION: Each tablet contains; Vitamin B1 (thiamine mononitrate) 100 mg, vitamin B6 (pyridoxal HCl) 200 mg and vitamin B12 (cyanocobalamin) 200 mcg.
Each 3ml ampoule contains Vitamin B1 (thiamine HCI) 100 mg, vitamin B6 (pyridoxal HCI) 100 mg and vitamin B12 (cyanocobalamin) 1000 mcg. Neurobion is a combination of 3 essential neurotropic vitamins of the B group.
ACTIONS:Pharmacology:Neurobion contains vitamins B1, B6 and B12 which act as co-enzymes and accordingly constitute substances essential for the metabolism. Their role in the metabolism of peripheral and central nerve cells, as well as their concomitant cells, must be seen in correlation with the maintenance of the structural and functional properties of the nervous system.
INDICATIONS: Neurological and other disorders associated with disturbances of the metabolic functions influenced by B-complex vitamins, including diabetic neuropathy and alcohol peripheral neuritis. Treatment of neuritis and neuralgia of the spinal nerves, spinal facial paresis, cervical syndrome, low back pain or ischialgia and herpes zoster.The vitamins B1, B6 and B12 are indispensable for a normal course of metabolism. Neurobion coated tablets are prescribed in neuralgia and pain in the spinal region,
DOSAGE & ADMINISTRATION: Tablet: 1tablet daily unless otherwise prescribed by the physician. Larger doses may be administered as deemed necessary by the physician.
Pregnancy:1 tab daily.
Ampouless: Severe Cases: 1 amp daily by deep IM; at best, slow intragluteal injection until the disappearance of the acute symptoms.
Milder Cases and Follow-Up Treatment: 1 amp 2-3 times weekly. Because of the possibility of sensitization against vitamin B1, Neurobion IV injection should be made cautiously and slowly while observing the patient for possible allergic reaction, Combination with glucose solution is often beneficial in IV injection.
Administration: Tablet: Swallow the tablets unchewed with a little liquid during or after meals.
CONTRAINDICATIONS: Hypersensitivity to any of the active ingredients or excipients of Neurobion.
Use in children:Neurobion is contraindicated in the treatment of children due to the high content of its active ingredients. In application of solution for injection containing benzylalcohol, treatment of children <3 years should be avoided, due to the risk of fatal toxic reactions arising from exposure to benzyl alcohol in excess of90 mg/kg body weight/day,
INTERACTIONS: The effect of levodopa may be reduced when vitamin B6 is administered concomitantly
SIDE EFFECTS: Hypersensitivity reactions, such as sweating, tachycardia, and skin reactions with itching and urticaria may occur with tablets very rarely (< 1/10,000). However, for gastrointestinal complaints, such as nausea, vomiting, diarrhoea and abdominal pain the frequency is unknown (i.e. cannot be estimated from the current data). For Neurobion injection, anaphylactic shock, injection site reactions, individual cases of acne or eczema have been reported very rarely after high parenteral doses of vitamin B12.
STORAGE: Store below 30 C. Avoid exposure to be sunlight heat and moisture